Contribution of Anti-platelet Antibodies Identified With MAIPA Assay in the Demonstration of the Auto-immune Character of a Thrombocytopenia at Diagnosis

  • STATUS
    Recruiting
  • End date
    May 2, 2025
  • participants needed
    225
  • sponsor
    University Hospital, Bordeaux
Updated on 2 June 2021
platelet count
acute leukemia
monoclonal antibodies
platelet aggregation
leukemia
thrombocytopenia
autoimmune disease
immune globulin

Summary

Immune thrombocytopenia (ITP) is an autoimmune disease but, paradoxically, and unlike other autoimmune diseases, antiplatelet antibodies are not used either for the diagnosis of the disease or for its prognosis. ITP is a diagnosis of exclusion retained after elimination of other pathologies leading to a thrombocytopenia. No major study has prospectively evaluated the diagnostic value of the presence of anti-platelet antibodies in the etiological investigation of a thrombocytopenia, nor the impact of platelet antibodies on the course of ITP. The gold standard analysis for the determination of platelet antibodies, is the "monoclonal antibody immobilization of platelet antigens" assay (MAIPA), either direct to detect autoantibodies attached to platelets, or indirect to detect circulating antiplatelet antibodies. Therefore, this work aims to study the contribution of the presence of anti-platelet antibodies detected in MAIPA to determine the autoimmune nature of a thrombocytopenia at diagnosis.

Details
Condition Idiopathic Thrombocytopenic Purpura (ITP), Thrombocytopenia and Thrombocytopenia Prevention, myelodysplastic syndrome (mds), IDIOPATHIC THROMBOCYTOPENIC PURPURA, Autoimmune disease, Immune Thrombocytopenia, myelodysplastic syndromes, myelodysplasia, Thrombocytopenic, autoimmune thrombocytopenia, Thrombocytopenia, Autoimmune Disease, Myelodysplastic Syndromes (MDS), Preleukemia, MYELODYSPLASTIC SYNDROME
Treatment blood samples
Clinical Study IdentifierNCT04800458
SponsorUniversity Hospital, Bordeaux
Last Modified on2 June 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patient over 18 years old
Patients with thrombocytopenia <100 G/L, checked twice, having ruled out false thrombocytopenia by platelet aggregation and acute leukemia by smear
No treatment started
Free, informed and written consent signed by the participant and the investigator (no later than the day of inclusion and prior to any review required by the research)
Person affiliated or benefiting from a social security scheme

Exclusion Criteria

Secondary ITP
False thrombocytopenia
Patients who have been transfused with platelets (<10 days)
Patient with acute leukemia
Pregnant or breastfeeding woman
False thrombocytopenia
Patient under guardianship, curatorship or any other legal protection regime
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