Photobiomodulation for the Management of Temporomandibular Disorder Pain

  • End date
    Mar 1, 2028
  • participants needed
  • sponsor
    University of Florida
Updated on 4 June 2021


Photobiomodulation (PBM), is FDA-approved for temporary relief of muscle and joint pain, but there is no indication for TMD. Our goal in this study is to conduct a clinical trial of multimodal PBM for TMD pain. Also, we propose to determine if PBM-induced changes in inflammation contribute to PBM's analgesic effects. This study will be a double-blind, sham-controlled, randomized trial testing the efficacy of PBM for pain related to TMD.

Condition Pain Related to TMD
Treatment THOR® laser system, sham THOR® laser system
Clinical Study IdentifierNCT04415281
SponsorUniversity of Florida
Last Modified on4 June 2021


Yes No Not Sure

Inclusion Criteria

Provides a signed and dated informed consent form
Is at least 18 years of age (male or female and any race or ethnicity)
Meets diagnostic criteria for TMD, ( Masticatory Muscle Disorders, 1A: Myalgia)
Has experienced facial pain for at least 3 months
At Screening and Baseline Visit (Visit 0), reports an average pain intensity rating over the past week of 30 on a numerical rating scale (0-100)

Exclusion Criteria

Starting a new daily prescription medication for the management of pain within 30 days prior to treatment session
Use of any injection therapy (e.g., tender or trigger point injections, steroid injections) for the management of pain within 2 weeks prior to the CATI
Starting occlusal appliance therapy within 30 days prior to CATI; d) history of facial trauma or orofacial surgery within 6 weeks prior to CATI
Active orthodontic treatment
Psychiatric hospitalization within one year prior to screening
Has known hypersensitivity to laser therapy
Currently being treated with chemotherapy or radiation therapy
Has been treated with another investigational drug or treatment within 30 days prior to the Screening and Baseline Visit
Is pregnant or nursing
Anything that, in the opinion of the investigator, would place the participant at increased risk or preclude the participant's full compliance with or completion of the study
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note