Autoreactivity Threshold Analysis in Lupus and Immune Thrombocytopenia (Checkpoints ITP and SLE)

  • End date
    Apr 29, 2022
  • participants needed
  • sponsor
    Assistance Publique - Hôpitaux de Paris
Updated on 30 May 2021
immune tolerance
immune globulin


The aim of this proposal is to test if anti-BAFF antibody can restore a normal threshold of tolerance in patients in two auto-immune diseases along the RITUX-PLUS study in immune thrombocytopenia, and along the Believe study in SLE. This work would help to conclude whether or not the 'double hit' therapy may help to reset the immune system toward a more tolerogenic profile.

The aim is to compare the polyreactivity and autoreactivity, of immature (central tolerance) and nave B cells (peripheral tolerance) in the peripheral blood along the RITUX-PLUS STUDY and the BLISS BELIEVE study after treatment (B-cell reconstitution time).

Condition Autoimmune disease, Idiopathic Thrombocytopenic Purpura (ITP), CONNECTIVE TISSUE DISEASE, autoimmune thrombocytopenia, Thrombocytopenic, Systemic Lupus Erythematosus, IDIOPATHIC THROMBOCYTOPENIC PURPURA, Autoimmune Disease, Immune Thrombocytopenia, SYSTEMIC LUPUS ERYTHEMATOSUS, Connective Tissue Diseases, Dermatomyositis (Connective Tissue Disease)
Treatment Bliss-Believe
Clinical Study IdentifierNCT03975361
SponsorAssistance Publique - Hôpitaux de Paris
Last Modified on30 May 2021


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