Zanubrutinib Combined With R-CHOP in Newly-diagnosed Intravascular Large B-cell Lymphoma
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- STATUS
- Recruiting
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- End date
- Apr 1, 2025
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- participants needed
- 20
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- sponsor
- Peking Union Medical College Hospital
Summary
This is a prospective single-arm phase II study, and the purpose of this study is to evaluate the efficiency of zanubrutinib combined with R-CHOP regimen in newly diagnosed primary intraocular lymphoma. Progression-free survival (PFS) of the cohort is the primary endpoint.
Description
All the eligible patients will be treated with ZR-CHOP regimen (Rituximab 375mg/m2 IV d1, cyclophosphamide 750mg/m2 IV d1, epirubicin 70mg/m2 IV d1, vindesine 4mg IV d1prednison 60mg/m2 d1-5 PO). An interim evaluation will be performed after 4 cycles, the patients who achieve CR or PR will receive another 4 cycles of ZR-CHOP.
The patients with stable disease (SD) or progressed disease (PD) will withdraw from the trial and receive salvage regimens.
During the following-up, surveillance physical examination and CT scans should be performed every 6 months for 2 years to determine the status of disease.
Details
| Condition | Intravascular Large B-Cell Lymphoma |
|---|---|
| Treatment | Rituximab, cyclophosphamide, prednisone, Epirubicin, Vindesine, Zanubrutinib |
| Clinical Study Identifier | NCT04899570 |
| Sponsor | Peking Union Medical College Hospital |
| Last Modified on | 4 June 2021 |
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