Flu-Bu-Mel Based Conditioning Regimen for Patients With Lymphoid Malignancies Undergoing Allo-HSCT

  • End date
    Jan 1, 2024
  • participants needed
  • sponsor
    Shanghai Jiao Tong University School of Medicine
Updated on 4 June 2021


In this phase II clinical trial, we evaluate the efficacy and feasibility of conditioning regimen of fludarabine 150mg/m2, busulfan 9.6mg/kg, melphalan 100mg/m2 and etoposide 800mg/m2 in patients with lymphoid malignancies.

Condition Lymphoid Neoplasm
Treatment Flu-Bu-Mel-E
Clinical Study IdentifierNCT04897139
SponsorShanghai Jiao Tong University School of Medicine
Last Modified on4 June 2021


Yes No Not Sure

Inclusion Criteria

lymphoid malignancies
donor available: HLA matched sibling, unrelated donor or haplo-identical related donor
patients with ECOG <3

Exclusion Criteria

inform consent not provided
ECOG >=3
poor liver function (enzyme >2N or bilirubin >2N)
poor renal function (Scr >2N)
poor cardiac function (EF <45%)
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