EGFR-targeted Therapy for Gastric Cancer

  • End date
    Dec 31, 2023
  • participants needed
  • sponsor
    National Cancer Center, Korea
Updated on 24 May 2021


Based on targeted NGS panel results, metastatic gastric cancer patients with gene amplifications will receive either anti-EGFR antibody (GC-1118) in combination with weekly paclitaxel as a second-line therapy.


Participants will receive each treatment if the gastric cancer tissue sample reveals either EGFR gene amplification or strong (3+ or 2+) EGFR immunostaining

Condition Gastric Adenocarcinoma, Adenocarcinoma of the Stomach, stomach adenocarcinoma
Treatment Anti-EGFR antibody in combination with weekly paclitaxel
Clinical Study IdentifierNCT04077255
SponsorNational Cancer Center, Korea
Last Modified on24 May 2021


Yes No Not Sure

Inclusion Criteria

Histologically-proven gastric and gastroesophageal junction adenocarcinoma
Refractory to first-line chemotherapy for metastatic disease
Presence of at least 1 measurable lesion according to RECIST version 1.1
EGFR gene amplification or strong (3+ or 2+) EGFR immunostaining

Exclusion Criteria

Prior exposure to taxane or EGFR-targeted therapy
Clear my responses

How to participate?

Step 1 Connect with a study center
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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