TQB2450 Combined With Anlotinib Hydrochloride in the Perioperative Treatment of Hepatocellular Carcinoma Hydrochloride Neoadjuvant Therapy for Resectable Hepatocellular Carcinoma With a High Risk of Recurrence or Metastasis

  • End date
    Jul 30, 2024
  • participants needed
  • sponsor
    Chinese Academy of Medical Sciences
Updated on 24 May 2021


In this study, single cell transcriptome sequencing will be performed on the tissue samples punctured and the surgically resected specimens to explore the gene mutation sites related to efficacy

Condition Patients With Resectable Hepatocellular Carcinoma Who Are at High Risk of Recurrence or Metastasi
Treatment Anlotinib hydrochloride capsules+ TQB2450 injection
Clinical Study IdentifierNCT04888546
SponsorChinese Academy of Medical Sciences
Last Modified on24 May 2021


Yes No Not Sure

Inclusion Criteria

consecutive years of disease-free survival (DFS) for other malignancies treated with a single operation;Cured carcinoma in situ of the cervix, non-melanoma skin cancer, and superficial bladder tumor [Ta (non-invasive tumor), Tis (carcinoma in situ), and T1 (tumor infiltrating basement membrane)]; 5 . There are many factors that affect oral medications (such as inability to swallow, chronic diarrhea, intestinal obstruction, etc.)
Hepatitis B combined with hepatitis C; 7. Patients with portal hypertension have high bleeding risk considered by the researcher, or gastroscopy or gastroscopy confirmed red signs, or gastroscopy found active ulcers with high bleeding risk

Exclusion Criteria

Fibrolamellar HCC, sarcomatoid HCC, or mixed bile duct cell-HCC is known to exis
Preoperative systemic treatment including chemotherapy, targeted therapy and immunotherapy;Preoperative local treatment including radiotherapy, interventional therapy and ablative therapy
No radical resection could be performed after adequate imaging evaluation
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