Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04)
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- STATUS
- Recruiting
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- End date
- Oct 19, 2024
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- participants needed
- 168
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- sponsor
- ALX Oncology Inc.
Summary
A Phase 2 Study of Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma.
Description
This is a open-label, randomized phase 2 multi-center study of the anti-tumor efficacy of evorpacept (ALX148) + pembrolizumab + 5FU + platinum and of pembrolizumab + 5FU + platinum in patients with metastatic or unresectable, recurrent HNSCC who have not yet been treated for their advanced disease. The study comprises of an initial safety lead-in followed by a randomized portion.
Details
| Condition | Head and Neck Cancer, Squamous Cell Carcinoma of Head and Neck, head and neck cancer, cancer of the head and neck, Squamous Cell Carcinoma of the Head and Neck, Head and Neck Squamous Cell Carcinoma |
|---|---|
| Treatment | Pembrolizumab, ALX148, Cisplatin/Carboplatin; 5FU, Evorpacept |
| Clinical Study Identifier | NCT04675333 |
| Sponsor | ALX Oncology Inc. |
| Last Modified on | 19 November 2021 |
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