Protocol Design of Hand Robotics Assisted Therapy in Patients With Different Severity of Stroke

  • days left to enroll
  • participants needed
  • sponsor
    Chang Gung Memorial Hospital
Updated on 23 May 2021


Some studies have shown that the end-effector type of hand robotic-assisted therapy (RT) can effectively improve upper extremity (UE) motor function in patients with stroke. However, these studies provide insufficient information on treatment protocol, making it difficult for therapists to apply the RT in clinical practice. This study aims to develop an end-effector RT treatment protocol and to examine the preliminary effects of the treatment protocol on UE motor function in patients with stroke.


There are two objectives in this case series study. One is combining external scientific evidence with clinical expertise to design a detailed training protocol for RT in patients with different severity of stroke. The other is to examine the effects on UE motor function and explore the client perspective.

The training protocol was developed based on the ACE Star Cycle Knowledge Transformation Model, which includes steps such as summarizing previous evidence and adjusting the protocol after practice by therapists. Purposive sampling will be used to recruit 35patients with stroke with different severities (Brunnstrom stage of distal part: 10 for stage II~III /10 for stage IV /15 for stage V~VI) from a regional hospital in Taiwan. Each participant will receive 12-15 sessions of 50-60 minutes intervention over 3 weeks. Motor function evaluations will be administered before and after the intervention. Wilcoxon Signed Rank test will be used to examine the change between the pretest and posttest.

Condition cerebrovascular accidents, Stroke, strokes, cerebral, Cerebrovascular accident
Treatment Amadeo-assisted training-1, Amadeo-assisted training-2, Amadeo-assisted training-3
Clinical Study IdentifierNCT04436627
SponsorChang Gung Memorial Hospital
Last Modified on23 May 2021


Yes No Not Sure

Inclusion Criteria

(1) Unilateral stroke patients diagnosed by neurologists with stable life conditions
(2) Twenty years old or older
(3) Modified Ashworth Scale of proximal UE 3 (shoulder and elbow), and Modified Ashworth Scale of distal UE 2 (wrist and fingers)
(4) UE subscale of Fugl-Meyer Assessment score < 60
(5) Cognitive test with the Mini Mental State Examination 21
(6) Can provide informed consent

Exclusion Criteria

(1) Joint contracture greater than 10 in the paretic wrist or hand
(2) Absence of proprioception in the wrist and hand
(3) Other neurological or psychological disorders, e.g. Parkinson's disease
(4) Receiving Botulinum toxin injections within 3 months
(5) Enrolling in other rehabilitation experiments or drug studies within 3 months
(6) unable to operate the AMADEO training system or who may have safety concern
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note