Basket trial concept to independently and simultaneously assess the effects of the
association of atezolizumab + BDB001 + radiotherapy in multiple solid tumors.
6 independent, multicenter, prospective, single-arm phase II trials, based on 2-stage Simon's
optimal design, will be conducted in parallel to assess the efficacy of atezolimab + BDB001+
radiotherapy, separately, in distinct populations of solid tumors:
Population 1: pancreatic cancer
Population 2: virus-associated tumors
Population 3: anti-PD-1/L1 refractory non-small lung cancer
Population 4: soft-tissue sarcoma
Population 5: anti-PD-1/L1 refractory bladder cancer
Population 6: triple negative breast cancer
Pancreatic Disorders, Virus-associated Tumors, Urologic Cancer, melanoma, pancreatic cancers, nsclc, Digestive System Neoplasms, bladder disorder, bladder tumor, cancer of the pancreas, urinary tract neoplasm, Pancreatic disorder, Neoplasm of unspecified nature of digestive system, Melanoma, Solid Tumor, Adult, skin cancer, Pancreatic Cancer, cancer, pancreatic, Bladder Cancer, Malignant Melanoma, Skin Cancer, bladder cancer, Breast Cancer, Bladder Disorders, Triple Negative Breast Cancer, Urothelial Cancer, Metastatic Melanoma, Bladder Carcinoma, Islet Ce417ll Cancer, Non-Small Cell Lung Cancer, carcinoma of the bladder
Association atezolizumab + BDB001 + RT,
Association atezolizumab + BDB001+ RT
If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
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