Rifabutin-containing Triple Therapy for Treatment of Helicobacter Pylori

  • days left to enroll
  • participants needed
  • sponsor
    Shanghai Jiao Tong University School of Medicine
Updated on 12 May 2022


Rifabutin has good chemical stability and low drug resistance rate in acidic gastric environment. Therefore, it is often used in combination with amoxicillin proton pump inhibitor for the rescue treatment of Helicobacter pylori. The purpose of this study was to evaluate the efficacy and safety of rifabutin-containing triple therapy versus classical bismuth-containing quadruple therapy as rescue therapy for the eradication of refractory Helicobacter pylori

Condition Helicobacter Pylori Infection
Treatment Esomeprazole, Bismuth Potassium Citrate, Tetracycline,Metronidazole, amoxicillin rifabutin
Clinical Study IdentifierNCT04879992
SponsorShanghai Jiao Tong University School of Medicine
Last Modified on12 May 2022


Yes No Not Sure

Inclusion Criteria

ability and willingness to participate in the study and to sign and give informed consent
Confirmed H. pylori infection and with previous treatment experience

Exclusion Criteria

Less than 18 years old
With previous gastric surgery
Previous history of tuberculosis
Major systemic diseases
Pregnancy or lactation
Allergy to any of the study drugs Administration of antibiotics, bismuth, antisecretory drugs in 8 weeks prior to inclusion
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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