Registry of the Natural History of Recurrent Pericarditis in Pediatric and Adult Patients (RESONANCE)

  • End date
    Feb 11, 2026
  • participants needed
  • sponsor
    Kiniksa Pharmaceuticals (UK), Ltd.
Updated on 11 October 2022


The registry will focus on furthering the understanding of the natural history of recurrent pericarditis (RP), as well as document RP-related clinical, health-related quality of life (HRQoL), and economic burden and will assist the medical community to refine or develop data-driven recommendations for clinical management of RP patients to optimize clinical outcomes. It also aims to generate data in support of the impact of rilonacept on clinical outcomes in a real-world population.

Condition Recurrent Pericarditis
Clinical Study IdentifierNCT04687358
SponsorKiniksa Pharmaceuticals (UK), Ltd.
Last Modified on11 October 2022


Yes No Not Sure

Inclusion Criteria

Physician-confirmed (or confirmation in medical records) diagnosis of RP defined as an initial, acute, episode and at least one pericarditis recurrence after the initial, acute episode
Patient had a last episode occurring at least 3 years and up to 5 years before registry inclusion
Resolution of RP symptoms confirmed with no further RP treatment for 3 years prior to registry enrollment

Exclusion Criteria

Experienced a pericarditis episode within 3 years from enrolling in the registry
Currently receiving RP treatment prescribed by a treating physician (e.g., CS, colchicine)
Diagnosis of pericarditis secondary to tuberculosis (TB), cancer if not in full remission, post thoracic blunt trauma (e.g., motor-vehicle accidents), myocarditis, systemic autoimmune diseases except SJIA and adult Still's disease, HIV
Enrolled in a therapeutic investigational clinical trial during the observation period
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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