Magnetic Stimulation as a Treatment for Auditory Hallucinations in Schizophrenia

  • participants needed
  • sponsor
    St. Joseph's Healthcare Hamilton
Updated on 7 November 2020
typical antipsychotic
auditory hallucinations


Schizophrenia is a chronic, severe, and disabling brain disease. Auditory hallucinations are the most frequent symptoms with an incident of 50% to 70% in patients. Transcranial Magnetic Stimulation (TMS) can significantly reduce symptoms of schizophrenia. TMS is capable of inducing changes in the electrical activities of the brain in humans. The purpose of this trial is to study the use of TMS to decrease auditory hallucinations in schizophrenia.


We hypothesize that: True treatment with rTMS will have significant decrease in auditory hallucinations versus sham treatment over the temporoparietal cortex. FMRI will highlight areas of activation with auditory hallucinations distinct from the area identified by Hoffman's scalp based method. Cortical inhibition as measured by paired pulse TMS will be increased after true TMS but not sham TMS.

Condition Schizophrenia
Treatment Paired Pulse
Clinical Study IdentifierNCT00186771
SponsorSt. Joseph's Healthcare Hamilton
Last Modified on7 November 2020


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