Study to Investigate the Safety and Efficacy of BRII-835 and BRII-179 Combination Therapy Treating Chronic HBV Infection

  • End date
    Jul 8, 2023
  • participants needed
  • sponsor
    Brii Biosciences Limited
Updated on 8 August 2021
Lili Chen
Primary Contact
Investigative Site 61004 (4.2 mi away) Contact
+27 other location


This is an open label, randomized, parallel-group study to evaluate the safety and efficacy of combination treatment BRII-835 (VIR-2218) and BRII-179 (VBI-2601) in adult participants with chronic HBV infection

Condition chronic hepatitis b
Treatment BRII-835 (VIR-2218), BRII-179 (VBI-2601) with IFN-α, BRII-179 (VBI-2601)
Clinical Study IdentifierNCT04749368
SponsorBrii Biosciences Limited
Last Modified on8 August 2021


Yes No Not Sure

Inclusion Criteria

Male or female aged 18 - 60
Body mass index 18 kg/m^2 and 32 kg/m^2
Chronic HBV infection as defined by a positive serum HBsAg for 6 months

Exclusion Criteria

Any clinically significant chronic or acute medical condition that makes the volunteer unsuitable for participation
Significant fibrosis or cirrhosis
History or evidence of drug or alcohol abuse
History of intolerance to SC or IM injection
History of chronic liver disease from any cause other than chronic HBV infection
History of hepatic decompensation
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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