Phenotype Genotype and Biomarkers 2

  • STATUS
    Recruiting
  • End date
    Jun 14, 2024
  • participants needed
    300
  • sponsor
    University of Miami
Updated on 14 July 2021
dementia
hereditary spastic paraplegia
atrophy
primary lateral sclerosis
frontotemporal dementia
progressive muscular atrophy
paraplegia
amyotrophic lateral sclerosis

Summary

The purpose of this study is to learn more about amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases, including frontotemporal dementia (FTD), primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), progressive muscular atrophy (PMA) and multisystem proteinopathy (MSP). More precisely, the investigator wants to identify the links that exist between the disease phenotype (phenotype refers to observable signs and symptoms) and the disease genotype (genotype refers to your genetic information). The investigator also wants to identify biomarkers of ALS and related diseases.

Details
Condition Frontotemporal Dementia, Spinal Muscular Atrophy, Myelopathy, Hereditary spastic paraplegia, Hereditary motor and sensory neuropathy, Pick's Disease, Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Neuropathy, Amyotrophic Lateral Sclerosis (ALS), Spinal Cord Disorders, primary lateral sclerosis, lateral sclerosis, progressive muscular atrophy, dementia, frontotemporal, lou gehrig's disease
Clinical Study IdentifierNCT04875416
SponsorUniversity of Miami
Last Modified on14 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Clinical diagnosis or suspicion of ALS or a related disorder, including, but not limited to, ALS-FTD, PLS, HSP, FTD, Multisystem Proteinopathy (MSP) and PMA
Subject is able and willing to comply with study procedures

Exclusion Criteria

Subjects with a condition or who are in a situation which, in the PI's opinion, could confound the study finding or may interfere significantly with the individual's participation and compliance with the study protocol -- including but not limited to neurological, psychological and/or medical conditions
Inclusion criteria for biological family members (secondary participants)
include
Family member of an enrolled affected primary participant
Exclusion Criteria for biological family members (secondary participants)
include
Subjects with a condition or who are in a situation which, in the PI's opinion, could confound the study finding or may interfere significantly with the individual's participation and compliance with the study protocol -- including but not limited to neurological, psychological and/or medical conditions
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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