Treating Postictal Symptoms Using Ibuprofen and Nifedipine

  • End date
    Mar 1, 2025
  • participants needed
  • sponsor
    University of Calgary
Updated on 11 May 2021


This study will evaluate the effect of ibuprofen or nifedipine on post-seizure hypoperfusion and neurological deficits in patients with epilepsy. One group will receive ibuprofen, another will receive nifedipine, and anther placebo.


Immediately following seizures, brain blood flow is significantly reduced for approximately one hour and is located to the brain area where the seizure originated. This may contribute to symptoms that patients experience immediately following seizures and in between seizures.

Animal studies have shown that that giving anti-inflammatory drugs (e.g., ibuprofen) and blood pressure medications (e.g., nifedipine) prevents the hypoperfusion and behavioural impairments seen in animals immediately following seizures. Thus, two classes of inexpensive and well-tolerated drugs - already in clinical use - have been identified that can be tested in humans to prevent the serious consequences that follow seizures.

The investigators will study 90 subjects admitted to hospital for epilepsy investigations. The investigators will randomly divide the patients into three treatment groups (30 patients each). Patients will receive either placebo, ibuprofen, or nifedipine while in hospital. The effect of each of these treatments on the severity of hypoperfusion and neurological deficits that follows seizures will then be assessed.

Condition Epilepsy, Epilepsy, Seizure Disorders, Seizure Disorders (Pediatric), Focal epilepsy, Seizure Disorders (Pediatric), Seizure Disorders, epileptic, seizure disorder, epilepsia, epileptics
Treatment Placebo, nifedipine, ibuprofen
Clinical Study IdentifierNCT03949478
SponsorUniversity of Calgary
Last Modified on11 May 2021


Yes No Not Sure

Inclusion Criteria

age > 16 yrs, frequent seizures (>1 per week) and cognitive ability sufficient to complete neuropsychological testing

Exclusion Criteria

multiple seizure onset zones, contraindications to CT or MR imaging, any contraindication to ibuprofen or nifedipine, as well as current or recent (< 2 months) exposure COX-2 inhibitor or calcium channel blocker
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