Uncovering a Novel Therapeutic Target to Reduce Dementia Risk in Parkinson's Disease (TRIP)

  • STATUS
    Recruiting
  • End date
    Dec 10, 2023
  • participants needed
    28
  • sponsor
    The University of Queensland
Updated on 25 January 2022
cognitive impairment
dementia
Accepts healthy volunteers

Summary

The present study is a proof-of-concept clinical trial to test the efficacy of low doses of a repurposed anti-epileptic drug (levetiracetam) in treating memory problems in Parkinson's disease (PD). Neuroimaging techniques will be used to determine the effect of the drug on specific brain regions (hippocampal subfields). Finally, baseline brain activity of PD patients with memory problems will be compared to PD patients without memory problems and healthy older adults to determine if activity in specific brain regions (hippocampal subfields) can be used to predict memory problems in PD. This information will be useful for future clinical trials to target drugs to these brain regions.

Details
Condition Parkinson Disease, Mild Cognitive Impairment, Memory Impairment
Treatment Placebo, Levetiracetam
Clinical Study IdentifierNCT04643327
SponsorThe University of Queensland
Last Modified on25 January 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Parkinson's Disease patients with amnestic Mild Cognitive Impairment
Parkinson's Disease patients with no memory impairment
Healthy volunteers
All participants must be eligible to take MRI scans

Exclusion Criteria

Dementia
Contraindication to having MRI
Bipolar disorder, Schizophrenia, Alcohol or substance abuse
Major depression
Suicidal Ideation
Difficulty complying with protocol requirements
Significant non-PD neurological disease
Vascular dementia
Sensitivity to levetiracetam
Use of anticonvulsant medications
Use of other excluded medications
Severe renal impairment
Clinically significant abnormalities in B12 or thyroid function test (below normative range for elderly)
Females of childbearing potential
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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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