Ketamine in Patients Undergoing TEVAR Procedures Receiving NCI (2020Ketamine)

  • STATUS
    Recruiting
  • End date
    Aug 1, 2023
  • participants needed
    20
  • sponsor
    Anna Rockich
Updated on 9 June 2022
anesthesia
ketamine
opioid

Summary

The objective of this study is to identify the opioid-sparing effects, and pain-reduction potential of low dose, sub-dissociative ketamine on patients undergoing thoracic endovascular aortic repair (TEVAR) procedures receiving naloxone continuous infusion (NCI).

Description

Patients undergoing descending aortic repair often experience post-operative pain, and have high post operative opioid requirements. That pain is partially due to the use of naloxone continuous infusion (NCI). NCI is part of a bundled approach used in the first 48 hours post-operatively to prevent spinal cord ischemia, a devastating complication associated with surgical repair of the descending aortic. Data indicate that patients receiving NCI experience elevated post-operative pain scores and increased opioid requirements during the 48-hr post-operative NCI administration, compared to patients not receiving NCI.

Ketamine is an FDA-approved N-methyl D-aspartate (NMDA) antagonist that has been shown to provide adjunctive analgesia and opioid-sparing effects in post-operative surgical patients. At low doses, ketamine provides analgesic benefit without the anesthetic effects seen at higher doses. These doses are commonly referred to sub-dissociative. This study will evaluate whether use of sub dissociative ketamine (SDK) in patients undergoing aortic procedures with the use of NCI will lead to decreased post-operative opioid consumption, and produce improved pain scores in the first 48 hours.

Details
Condition Descending Aortic Dissection, Postoperative Pain, Thoracoabdominal Aortic Aneurysm
Treatment Ketamine, Saline
Clinical Study IdentifierNCT04600089
SponsorAnna Rockich
Last Modified on9 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

willing to give informed consent
scheduled for elective thoracic aorta repair or thoracoabdominal aortic repair
requires naloxone continuous infusion for spinal prophylaxis

Exclusion Criteria

allergy to ketamine, acetaminophen, or fentanyl
diagnosis of schizophrenia
history of hydrocephalus or central nervous system mass
incarcerated individuals
pregnant or lactating individuals
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