Technology-Supported Treatment of Sleep Apnea in Prediabetes (TECH)

  • STATUS
    Recruiting
  • End date
    Jul 31, 2025
  • participants needed
    740
  • sponsor
    University of Chicago
Updated on 29 April 2022
diabetes

Summary

Despite the efficacy of intensive lifestyle interventions in prediabetes, the incidence of diabetes is rising, and thus there is a critical need for additional strategies to prevent diabetes and to reduce its cardiovascular complications in this high-risk population. Sleep apnea is a highly common condition in prediabetes, but it has been mostly ignored and undertreated in current practice. The proposed study will be the first to assess whether adding CPAP (continuous positive air pressure) treatment to a lifestyle intervention improves cardiometabolic outcomes beyond that achieved with lifestyle alone (i.e. current standard of care) in high-risk individuals with prediabetes.

Description

This is a 6-month randomized controlled, parallel group trial with two arms. After baseline, the subjects will be randomized to lifestyle intervention alone (lifestyle group) or lifestyle plus CPAP intervention (lifestyle plus CPAP group). The same metabolic and cardiovascular assessments will be performed at baseline and after 6-months of intervention.

The lifestyle group will aim to achieve a weight loss through diet and exercise. The lifestyle plus CPAP group will additionally receive CPAP treatment. All subjects will use a custom smartphone app to track weight loss and/or CPAP goals and will receive weekly coaching phone calls to maximize treatment adherence.

Details
Condition Sleep Apnea, PreDiabetes, Overweight or Obesity
Treatment CPAP Treatment, Diet and exercise coaching
Clinical Study IdentifierNCT04225507
SponsorUniversity of Chicago
Last Modified on29 April 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Overweight or obese
Prediabetes
Sleep apnea

Exclusion Criteria

Diabetic
enrolled in a formal weight loss program
Any underlying disease likely to limit life span and/or increase risk of interventions
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