Micromegaly and Discrepancy Between Growth Hormone and IGF1 at the Diagnosis and Follow-up of Acromegalic Patients

  • End date
    Dec 1, 2022
  • participants needed
  • sponsor
    University Hospital, Montpellier
Updated on 2 May 2021


The diagnosis and the follow-up of acromegalic patients are based on the mesurement of Growth hormone (GH) and IGF1 rates. However, the literature described some cases of patient for whom the investigators observed a discrepancy between GH and IGF1 rates. Since the acromegaly is a rare disease and this phenomenon concerns about 30% of these patients, there is a lack of investigations about consequences that this discordance may induces. In this study, the investigators aimed at assessing if patients with discordance between GH and IGF1 rates present a different risk of recurrence and complications related to acromegaly, from patients with concordant results.

Condition Acromegaly, Acromegaly
Clinical Study IdentifierNCT04860037
SponsorUniversity Hospital, Montpellier
Last Modified on2 May 2021


Yes No Not Sure

Inclusion Criteria

Acromegaly followed up in one of the center (Montpellier, Nimes or Bziers hospital, independent endocrinologist) between 2010 and 2021
Age over 18 years old
Measurement of GH and IGF1 rates at the last visit control available

Exclusion Criteria

Lost to follow-up
Status about complications related to acromegaly unknown
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