POCUS: Hemostatic Potential and Joint Health in Patients With Severe Hemophilia A on Novel Replacement Therapies
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- STATUS
- Recruiting
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- End date
- Jan 4, 2023
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- participants needed
- 28
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- sponsor
- University of Texas Southwestern Medical Center
Summary
This is a prospective, randomized control trial in which each patient will be randomly assigned to receive either extended half-life factor VIII based replacement therapy or non-FVIII based replacement therapy, which are both standard of care treatment for persons with Hemophilia A.
Description
This is a research study to find out if there is a difference in the way children with hemophilia A form a clot and also evaluate if they develop tiny bleeds within the joint and subsequently early joint changes when receiving extended half-life factor VIII based replacement therapy vs non-FVIII based replacement as part of their hemophilia treatment to prevent spontaneous joint bleeds.
Both therapies are standard of care therapies for patients with hemophilia A. The only experimental/research procedures as part of this study include the thrombin generation assay and ultrasound. All other procedures are standard of care.
Details
| Condition | Hemophilia A, Factor VIII |
|---|---|
| Treatment | ADYNOVATE, Emicizumab, Eloctate, Eloctate |
| Clinical Study Identifier | NCT04690322 |
| Sponsor | University of Texas Southwestern Medical Center |
| Last Modified on | 4 May 2022 |
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