The Effect of Acupuncture on IVF Pregnancy Outcomes for Women With RIF

  • STATUS
    Recruiting
  • End date
    Dec 31, 2024
  • participants needed
    514
  • sponsor
    Huazhong University of Science and Technology
Updated on 29 April 2021

Summary

The randomized, placebo-controlled multicenter trial is conducted in five centers in China. After screening and obtaining the signed informed consent , the participants are randomly divided into two groups: acupuncture +IVF group and sham acupuncture +IVF group.

Details
Condition Repeated Implantation Failure
Treatment acupuncture and IVF, sham acupuncture and IVF
Clinical Study IdentifierNCT04533295
SponsorHuazhong University of Science and Technology
Last Modified on29 April 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Married women aged 25-40
Repeated implantation failure for unknown reasons (after 3 or more consecutive cycles of embryo transfer, or cumulative transfer of 6 high-quality cleavage embryos or 4 high-quality blastocysts without clinical pregnancy)
Transplantable Day 3 high-quality frozen embryos or frozen blastocysts (3BB)
Estrogen and progesterone replacement therapy (HRT), endometrial thickness 7mm on the day of endometrial transformation

Exclusion Criteria

Patients who met any of the following conditions were not included
Those who prepare for PGD
Recipients of egg donors
Chromosomal abnormalities in both or one of the couples (excluding chromosome polymorphism)
patients with implantation failure due to known embryonic factors
Uterine lesions that may affect implantation (including uterine malformation, uterine tuberculosis, history of intrauterine adhesions, submucosal fibroids, adenomyosis, >4cm intramural fibroids)
Repeated spontaneous abortion (2 or more fetal loss before 28 weeks of gestation)
Patients with other endocrine diseases, such as thyroid disease, hyperprolactinemia, insulin resistance, diabetes, adrenal disease, etc., and poor control of hormone levels in the last 3 months
Clearly diagnosed autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, etc
Hydrosalpinx untreated
BMI less than 18 and higher than 25kg/m2
People with previous history of needle sickness
Those who had previously participated in this study or had received acupuncture treatment in the past 3 months
Any situation that researchers consider inappropriate for participating in this study
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

0/250

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note