The Effect of Acupuncture on IVF Pregnancy Outcomes for Women With RIF

  • End date
    Dec 31, 2024
  • participants needed
  • sponsor
    Huazhong University of Science and Technology
Updated on 29 April 2021


The randomized, placebo-controlled multicenter trial is conducted in five centers in China. After screening and obtaining the signed informed consent , the participants are randomly divided into two groups: acupuncture +IVF group and sham acupuncture +IVF group.

Condition Repeated Implantation Failure
Treatment acupuncture and IVF, sham acupuncture and IVF
Clinical Study IdentifierNCT04533295
SponsorHuazhong University of Science and Technology
Last Modified on29 April 2021


Yes No Not Sure

Inclusion Criteria

Married women aged 25-40
Repeated implantation failure for unknown reasons (after 3 or more consecutive cycles of embryo transfer, or cumulative transfer of 6 high-quality cleavage embryos or 4 high-quality blastocysts without clinical pregnancy)
Transplantable Day 3 high-quality frozen embryos or frozen blastocysts (3BB)
Estrogen and progesterone replacement therapy (HRT), endometrial thickness 7mm on the day of endometrial transformation

Exclusion Criteria

Patients who met any of the following conditions were not included
Those who prepare for PGD
Recipients of egg donors
Chromosomal abnormalities in both or one of the couples (excluding chromosome polymorphism)
patients with implantation failure due to known embryonic factors
Uterine lesions that may affect implantation (including uterine malformation, uterine tuberculosis, history of intrauterine adhesions, submucosal fibroids, adenomyosis, >4cm intramural fibroids)
Repeated spontaneous abortion (2 or more fetal loss before 28 weeks of gestation)
Patients with other endocrine diseases, such as thyroid disease, hyperprolactinemia, insulin resistance, diabetes, adrenal disease, etc., and poor control of hormone levels in the last 3 months
Clearly diagnosed autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, etc
Hydrosalpinx untreated
BMI less than 18 and higher than 25kg/m2
People with previous history of needle sickness
Those who had previously participated in this study or had received acupuncture treatment in the past 3 months
Any situation that researchers consider inappropriate for participating in this study
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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