Clinical Outcome in Patients With Syringomyelia COPSM

  • STATUS
    Recruiting
  • End date
    Apr 30, 2025
  • participants needed
    200
  • sponsor
    Xuanwu Hospital, Beijing
Updated on 13 June 2021

Summary

The aim of this study is to determine the clinical spectrum and natural progression of Syringomyelia (SM) and related disorders in a prospective single center study, identify digital, imaging and molecular biomarkers that can assist in diagnosis and therapy development and study the etiology and molecular mechanisms of these diseases.

Description

Syringomyelia is a chronic central spinal cord injury, which is characterized by dilation of the central canal of the spinal cord. At present, the treatment of syringomyelia is mainly through surgical decompression to restore the disturbance of cerebrospinal fluid circulation. Due to the heterogeneity of the etiology of syringomyelia, almost all published studies on the clinical outcome and prognostic factors of syringomyelia are relatively limited, and most of them are retrospective. It is not clear which is the most reliable predictor of clinical outcome. Therefore, the researchers conducted this prospective cohort study to identify the occurrence, development and outcome of syringomyelia and determine the main prognostic factors through clinical scales, biomarkers and electrophysiology.

At study visits a standardized clinical examination will be performed including application of clinical rating scales. At all study visits, patients will be asked to donate biosamples; biomaterial collection is optional and participants can elect to participate in sampling of blood, urine, CSF, and/or a muscle biopsy.

Optionally, additional examinations may be performed including imaging, neurophysiological examination, analysis of patient or observer reported outcomes and analysis to characterize molecular biomarkers.

Details
Condition Syringomyelia/Hydromyelia, Syringomyelia/Hydromyelia, Syringomyelia/Hydromyelia, Syringomyelia/Hydromyelia
Treatment high throughput sequencing and electromyography
Clinical Study IdentifierNCT04856839
SponsorXuanwu Hospital, Beijing
Last Modified on13 June 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

patients who was diagnosed as syringomyelia including: Chiari malformation Basilar Impression subarachnoid obstruction patient not received surgical or interventional treatment before patient willing and able to participate in the registry
Hydrocephalus or other neurodegenerative disease and normal subjects

Exclusion Criteria

patient received surgical treatment or interventional treatment before
patient is pregnant
patient unable to complete follow-up
patient with other spinal lesions
other nervous system diseases
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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