Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension Receiving Sildenafil

  • End date
    Dec 31, 2024
  • participants needed
  • sponsor
    University of Zurich
Updated on 25 April 2021


To study the effect of acute normobaric hypoxia during exercise in patients with pulmonary hypertension with/without Sildenafil

Condition Pulmonary Hypertension, Cancer Prevention, Surviving Abuse, Joint Injuries, Abdominal Surgery, Mental Disability, Pelvic Adhesions, Low Testosterone, Dental Filling, Habit Reversal, Complicated Grief, Chronic Pelvic Pain, Gambling Problems, Myopic Macular Degeneration, Nerve Injury, Severe Premenstrual Symptom, Stasis Dermatitis, Pulmonary Arterial Hypertension, Open Heart Surgery, Recurrent Pregnancy Loss, Effects of Chemotherapy, Renal Anemia, Functional Dyspepsia, Catheter Complications, Serial Evaluation of Ductal Epithelium, Chronic Renal Anemia, Cancer Treatment, Anemic Cancer, Spinocerebellar Disorders, Pseudobulbar Affect, Spine Athroplasty, Indikation: Diabetes - Typ II, Partial Medial Meniscectomy, Primary Insulin Hypersecretion, Testotoxikose, Infantile Fibrosarcoma, Late Infantile Neuronal Ceroid Lipfuscinsosis, Memory Problems
Treatment Normobaric hypoxia (FiO2 15%), Normobaric hypoxia (FiO2 15%) under Sildenafil
Clinical Study IdentifierNCT04697862
SponsorUniversity of Zurich
Last Modified on25 April 2021


Yes No Not Sure

Inclusion Criteria

Informed consent as documented by signature (Appendix Informed Consent Form)
PH class I (PAH) or IV (CTEPH) diagnosed according to guidelines: mean pulmonary artery pressure >20 mmHg, pulmonary vascular resistance 3 wood units, pulmonary arterial wedge pressure 15 mmHg during baseline measures at the diagnostic right-heart catheterization

Exclusion Criteria

resting partial pressure of oxygen <8 kilopascal at Zrich altitude on ambient air
exposure to an altitude >1000 m for 3 nights during the last 2 weeks before the study
inability to follow the procedures of the study
patients who take nitrates
other clinically significant concomitant end-stage disease (e.g., renal failure, hepatic dysfunction)
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