Analysis of the Evolution of SUVmax by Quantitative Analysis Method of Bisphosphonate Scintigraphy

  • STATUS
    Recruiting
  • End date
    Mar 7, 2025
  • participants needed
    30
  • sponsor
    GCS Ramsay Santé pour l'Enseignement et la Recherche
Updated on 7 May 2021

Summary

Recently, treatment with tafamidis in patients with cardiac ATTR lead to a significant reduction in mortality. The Perugini score is commonly used on planar bone scans to differentiate cardiac ATTR from other amyloidosis or normal patients but fails to evaluate amyloid burden and patient prognosis. Although semi-quantitative methods have been suggested to evaluate the amyloid burden, there a need for quantitative methods for longitudinal assessment of the disease.

Description

Cardiac amyloidosis is a cause of restrictive cardiomyopathy with preserved ejection fraction associated with amyloid fibrils deposits in the myocardium. Two types of amyloid commonly infiltrate the heart: immunoglobulin light-chain amyloid (AL), and transthyretin-related amyloid amyloidosis (ATTR). Cardiac imaging is currently used for the diagnosis of ATTR, including planar scintigraphy with bone seeking radiopharmaceuticals, cardiac magnetic resonance and echocardiography with global longitudinal strain assessment.Although semi-quantitative methods have been suggested to evaluate the amyloid burden, there a need for quantitative methods for longitudinal assessment of the disease.

Details
Condition Cardiac Amyloidosis
Treatment Bone scintigraphy
Clinical Study IdentifierNCT04849754
SponsorGCS Ramsay Santé pour l'Enseignement et la Recherche
Last Modified on7 May 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patient, male or female, over 18 years of age
Patient diagnosed with transthyretin cardiac amyloidosis confirmed by scintigraphy
Patient with signed consent

Exclusion Criteria

Patients with systemic AL amyloidosis
Protected patient : major under guardianship, tutorship or other legal protection, deprived of liberty by judicial or administrative decision
Pregnant or breastfeeding woman
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