Hypertension Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial)

  • STATUS
    Recruiting
  • participants needed
    120
  • sponsor
    University of Texas Southwestern Medical Center
Updated on 5 December 2022
electrocardiogram
hypertension
calcium
cognitive impairment
dementia
mini-mental state examination
amyloid
mental state examination
beta amyloid protein
antihypertensive drugs
angiotensin ii

Summary

The aim of this study is to determine if lowering blood pressure using FDA approved medication (antihypertensive drugs) alters brain pulsatility and reduces brain amyloid beta protein accumulation in older adults. Amyloid beta protein is high in the brain of older adults with Alzheimer's disease. Hypertension may increase brain amyloid beta protein accumulation and affect memory and thinking ability in older adults. However, whether lowering blood pressure reduces brain amyloid beta protein and improves brain function is inconclusive.
The investigators hypothesize that treating high blood pressure alters brain pulsatility, which in turn reduces brain amyloid beta protein accumulation and improves brain structure and function.

Description


Details
Condition Alzheimer's Disease, High Blood Pressure (Hypertension), High Blood Pressure (Hypertension - Pediatric), Diabetes and Hypertension, Vascular Diseases
Treatment Standard Care, Intensive Treatment
Clinical Study IdentifierNCT03354143
SponsorUniversity of Texas Southwestern Medical Center
Last Modified on5 December 2022

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