MRI-guided Lateral Lymph Node Dissection in Rectal Cancer

  • End date
    Dec 31, 2025
  • participants needed
  • sponsor
    Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Updated on 7 May 2021


To investigate the oncological outcome of lateral lymph node dissection in low rectal cancer based on MRI


Our study design is a multicenter, prospective, registry study.

We would enroll 268 patients with lower rectal cancer whose preoperative MRI showed laterally lymph node diameter 5mm.

The postoperative adjuvant chemoradiotherapy is determined by the pathological results. For patients of stage II and patients of stage III with unfavorable histologic features, six months of adjuvant chemotherapy of fluorouracil-based regimen with radiotherapy of 45.0 ~ 50.5 Gy are recommended.

The postoperative examination should be performed every three months in the first two years and every six months in the following three years.

Our study is expected to last five years, of which two years for recruiting patients, three years for follow-up.

Condition Colorectal Cancer, Colorectal Cancer, Colon Cancer Screening, Colon cancer; rectal cancer, Rectal Cancer, Rectal Cancer, Colon Cancer Screening, Colon cancer; rectal cancer, rectal carcinoma
Treatment TME+Lateral lymph node dissection.
Clinical Study IdentifierNCT04850027
SponsorCancer Institute and Hospital, Chinese Academy of Medical Sciences
Last Modified on7 May 2021


Yes No Not Sure

Inclusion Criteria

Age between 18-75 years old
Pathologically confirmed as rectal adenocarcinoma
The tumor is located in the middle or lower rectum
Preoperative MRI assessment is T2-4 N+M0
Lateral lymph node short diameter 5 mm (MRI)
Signed informed consent

Exclusion Criteria

Previous history of malignant colorectal tumors
Multiple abdominal or pelvic surgeries were performed
Complicated with bowel obstruction, perforation or bleeding
Patients undergoing palliative surgery
Patients with severe liver and kidney dysfunction, cardiopulmonary dysfunction, blood coagulation dysfunction, or combined with serious underlying diseases that cannot tolerate surgery
Have a history of severe mental illness
Pregnant or breastfeeding women 8) Patients previously treated with iliac artery surgery (or its branches)
(9) R0 resection cannot complete (10) ASA grade IV
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note