Elements Vital to Treat Obesity Study (EVO)

  • End date
    Jun 18, 2025
  • participants needed
  • sponsor
    Northwestern University
Updated on 18 May 2022
self monitoring
Accepts healthy volunteers


The overall objective of this study is to evaluate the first rigorously optimized, remotely delivered treatment for obesity against the current gold standard treatment in a head-to-head randomized controlled trial. The investigators will be comparing the previously developed and optimized behavioral weight loss intervention (APP) to the Diabetes Prevention Program (DPP), to evaluate program weight-loss success and cost-effectiveness.


The proposed study seeks to determine if the APP program is an effective, resource-sensitive strategy to manage weight for obesity, as compared to the DPP program. During the 24-week active intervention phase, participants will be randomized to one of two treatments: 1) APP, wherein participants receive calorie, fat, and physical activity goals via a Smartphone application for self-monitoring, online educational readings, and biweekly sessions with a Health Promotionist; or 2) DPP, wherein participants are guided to self-monitor their physical activity, food intake, and weight via a participant log, and are guided through 16 sessions by a Health Promotionist. Assessments to track progress will occur remotely at the 3-month, 6-month, and 12-month time points of the program.

Condition Obesity
Treatment Smartphone App Participants (APP), Diabetes Prevention Program Participants (DPP)
Clinical Study IdentifierNCT04708769
SponsorNorthwestern University
Last Modified on18 May 2022


Yes No Not Sure

Inclusion Criteria

BMI 30-45
Weight stable
Own a Smartphone and be willing to install our Smartphone app
Willing to conduct video conference calls with study staff

Exclusion Criteria

Enrolled in any formal weight loss program
Taking anti-obesity medications
Not taking medications that may cause weight gain
Unstable medical conditions
Diabetes requiring insulin supplementation
Crohn's Disease
Diagnosis of obstructive sleep apnea requiring intervention (i.e., CPAP)
Assistive devices for mobility
Hospitalizations for a psychiatric disorder within the past 5 years
Cardiovascular disease symptoms while performing moderate intensity exercise
Pregnancy, trying to get pregnant, or lactating
Bulimia or binge eating disorder
Reports of active suicidal ideation
Current substance abuse or dependence besides nicotine dependence
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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