ECCO2R in the Treatment of Acute Exacerbation of COPD With Severe Hypercapnia

  • STATUS
    Recruiting
  • End date
    Mar 31, 2024
  • participants needed
    176
  • sponsor
    Li Xuyan
Updated on 21 April 2021

Summary

Patients with moderate to severe acute exacerbation of chronic obstructive pulmonary disease are often complicated with hypercapnia and respiratory failure, so they need to be admitted to ICU for monitoring and respiratory support treatment. Noninvasive ventilation has become the first-line respiratory support for the treatment of AECOPD with hypercapnia and respiratory failure. However, 26-54% of AECOPD patients with hypercapnia and respiratory failure eventually fail to receive noninvasive ventilation and need endotracheal intubation and invasive ventilation to maintain effective gas exchange. For these patients, the in-hospital survival rate is only 31-76%, and the prognosis is poor. In AECOPD patients with high risk of noninvasive ventilation failure and expected need of intubation, timely giving other ways of respiratory support to reduce blood CO2 may avoid patients receiving tracheal intubation and invasive ventilation, thus avoiding related complications and adverse prognosis. As a new type of respiratory support technology, ECCO2R is worthy of attention in monitoring and evaluation of support effect in AECOPD patients with respiratory failure. It is urgent that ECCO2R can effectively alleviate respiratory failure, avoid complications related to tracheal intubation, improve quality of life and reduce mortality.

Details
Condition obstructive lung diseases
Treatment ECCO2R
Clinical Study IdentifierNCT04842344
SponsorLi Xuyan
Last Modified on21 April 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

AECOPD patients
The patients with hypercapnia respiratory failure were admitted to ICU and needed noninvasive ventilation
The results of blood gas analysis showed pH <7.30, PaCO2> 50 mmHg
There were high risk factors for failure of noninvasive ventilation: after receiving continuous 2 hours of noninvasive ventilation, the arterial blood pressure showed the pH value was 7.30, while PaCO2 was 20% higher than the baseline value, and any one or more of the following conditions were combined: respiratory rate 30 times / min, assisted respiratory muscle breathing; contradictory breathing
Informed consents were sighed

Exclusion Criteria

The mean arterial pressure was less than 60 mmHg after volume and vasoactive drug treatment
There were anticoagulant contraindications
Weight over 120kg
Patients with malignant tumor or other complications, the expected survival time was less than 30 days
It could not cooperate with noninvasive ventilation or has contraindication of noninvasive ventilation
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