NT-proBNP and Troponin I in Dengue Children

  • End date
    Dec 31, 2022
  • participants needed
  • sponsor
    Le Phuoc Truyen
Updated on 18 April 2021


To discribe concentration of NT-proBNP and Troponin I in Dengue hemorrhagic shock children, in correlation between concentration of NT-proBNP and troponin I with total fluid admission, respiratory support, using inotrope and vasopressor using.


Treatment of children with Dengue hemorrhagic shock syndrome (DSS) is challenge, especially in cases with hypotensive shock, profound shock or whom do not have a response to initial crystalloid therapy. Currently, treatment of DSS remains almost supportive, with particular emphasis on careful fluid management. However, fluid overload is a common complication of this treatment, lead to many difficulties in management of severe Dengue children, accompany with morbidity and mortality. Diagnosis of fluid overload mostly based on clinical features and chest X-ray or ultrasound. Until now, no biomarker are widely using for diagnosis of fluid overload in clinical. NT-proBNP is secreted when stretching the wall of the cardiac muscle. This may a suitable biomarker to discover the fluid overload state in children with DSS. Troponin I is a biomarker of cardiac muscle damage.

Condition Only Child, Dengue hemorrhagic fever, dengue shock syndrome
Clinical Study IdentifierNCT04837430
SponsorLe Phuoc Truyen
Last Modified on18 April 2021


Yes No Not Sure

Inclusion Criteria

Dengue shock children who admitted to ICU

Exclusion Criteria

Excluding the cases of children with cardiovascular disease, hyperthyroidism, taking drugs such as insulin, steroid, estrogen, growth hormone, thyroid hormone
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