MRI T2* Mapping of Myocardium Liver Pancreas and Pituitary Gland

  • STATUS
    Recruiting
  • End date
    Jan 21, 2023
  • participants needed
    152
  • sponsor
    Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Updated on 15 April 2021

Summary

All patients were investigated using a 3T MRI and 1,5 T MRI scanners. For myocardium, pancreas and pituitary gland iron overload quantification in children we have used special sequences for T2*-mapping.

Miocardium, pancreas and pituitary gland T2 relaxometry maps were calculated automatically by commertial application ReportCARD Functool (GE Healthcare) and integrated Philips T2 maps. Then for selected ROI T2* data acquisition in milisecond [ms] were performed and calculated automatically.

Description

All patients were investigated using a 3T MRI scanner (Philips Achieva) and 1,5 T MRI scanner (GE Signa) with 8-channel surface coil for body scanning. For myocardium, pancreas and pituitary gland iron overload quantification in children we have used special sequences for T2-mapping based on fast gradient echo sequences - multi-phase fast gradient echo and ultrashort gradient echo (uTE) in axial and coronary plane. For breath-hold acquisition due to failure of communication and invariable behavior some children received anaesthetic support with mechanical ventilation. Miocardium, pancreas and pituitary gland T2 relaxometry maps were calculated automatically by commertial application ReportCARD Functool (GE Healthcare) and integrated Philips T2* maps.

The placement of region of interest (ROI) in target organ were performed by following criterion: for the myocardium - in the interventricular septum in short axis plane; for the pancreas - in corpus in axial plane; for the pituitary gland - in adenohypophysis; for all organs the area of large and small blood vessels, which can introduce distortions of the obtained results were excluded. Then for selected ROI T2* data acquisition in milisecond [ms] were performed and calculated automatically by approximating the attenuation curve with the highest likelihood method.

Details
Condition Iron Overload, Iron Overload (Hemachromatosis), Iron Overload (Hemachromatosis)
Treatment Npf.
Clinical Study IdentifierNCT04835285
SponsorFederal Research Institute of Pediatric Hematology, Oncology and Immunology
Last Modified on15 April 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age under 25 y.o
A history of transfusion-dependent anemia of various origins
indications for the appointment of chelation therapy
Non-inclusion criteria
Age over 25 y.o
The number of RBC transfusions previously received by the patient is less than 10

Exclusion Criteria

Absolute contraindications to magnetic resonance imaging (pacemaker, ferromagnetic implants, etc.)
Refusal to sign the informed consent
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