Glucagon-like Peptide-1 in Type 1 Diabetes
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- STATUS
- Recruiting
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- End date
- Jul 27, 2024
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- participants needed
- 40
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- sponsor
- University of Maryland, Baltimore
Summary
The hypotheses to be tested in this application is: GLP-1 will acutely protect arterial endothelial function and reduce pro-atherothrombotic and pro-coagulant effects of repeated hypoglycemia in T1DM.
Description
The naturally occurring hormone GLP-1 when co-administered during hypoglycemia (low blood sugar) in non-diabetic individuals can reduce the deleterious effects of hypoglycemia on the vasculature. We have shown that IV infusion of GLP-1 during a single moderate episode of hypoglycemia can preserve endothelial function and protect the vasculature from pro-coagulant and pro-inflammatory effects in healthy individuals.
It is unknown whether GLP-1 could protect the vasculature during episodes of repeated hypoglycemia and whether GLP-1 would have protective effects in T1DM individuals.
Details
| Condition | Type1 Diabetes Mellitus |
|---|---|
| Treatment | placebos, Glucagon-like Peptide-1 |
| Clinical Study Identifier | NCT04355832 |
| Sponsor | University of Maryland, Baltimore |
| Last Modified on | 27 April 2022 |
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