COVID-19 Vaccination in Rheumatic Disease Patients

  • participants needed
  • sponsor
    Mayo Clinic
Updated on 29 January 2022


The research is being done to study the immune responses to COVID-19 vaccination in patients with rheumatic diseases.


Because patients treated with immunosuppressive agents have been excluded from initial clinical trials, and most patients with rheumatic diseases are taking immunosuppressants, the immune responses towards the mRNA COVID19 vaccines in these patients remains unknown. The goal is to study the immune response to COVID-19 vaccination in patients with rheumatic diseases. Blood samples collected before and longitudinally after mRNA-based COVID-19 vaccination (i.e., Pfizer and Moderna vaccines) will enable detailed immunological investigation of the interaction between COVID-19 vaccination and rheumatic diseases. These efforts will provide novel insights into the COVID-19 vaccine response in patients with rheumatic diseases, and eventually would inform clinical management to improve patient care.

Condition Ankylosing spondylitis, Ankylosing spondylitis, Psoriasis, Psoriasis and Psoriatic Disorders, Autoimmune disease, Autoimmune disease, CONNECTIVE TISSUE DISEASE, Connective Tissue Diseases, Dermatomyositis (Connective Tissue Disease), Sicca Syndrome, Sjogren's Syndrome, PSORIATIC ARTHRITIS, PSORIATIC ARTHRITIS, Rheumatoid Arthritis, Rheumatoid Arthritis, Rheumatoid Arthritis (Pediatric), SYSTEMIC LUPUS ERYTHEMATOSUS, SYSTEMIC LUPUS ERYTHEMATOSUS, Xerostomia, Dry Mouth, Arthritis, Arthritis and Arthritic Pain, Arthritis and Arthritic Pain (Pediatric), Gout, Gout (Hyperuricemia), Osteoarthritis, Osteoarthritis, Arthritis and Arthritic Pain, Gout (Hyperuricemia), Psoriasis and Psoriatic Disorders, Rheumatoid Arthritis (Pediatric), Dermatomyositis (Connective Tissue Disease), Arthritis and Arthritic Pain (Pediatric), Sjogren's Syndrome, Dry Mouth, Connective Tissue Diseases, degenerative arthritis, Inflammatory Myositis, Arthritis of Multiple Sites Associated With Inflammatory Bowel Disease (Diagnosis), Arthritis of Multiple Sites Associated With Inflammatory Bowel Disease (Diagnosis)
Treatment mRNA COVD19 vaccine
Clinical Study IdentifierNCT04839315
SponsorMayo Clinic
Last Modified on29 January 2022

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note