Influence of Respiratory Rate Settings on CO2 Levels During Nasal Intermittent Positive Pressure Ventilation (NIPPV).

  • STATUS
    Recruiting
  • End date
    Apr 1, 2023
  • participants needed
    50
  • sponsor
    Rambam Health Care Campus
Updated on 18 April 2021

Summary

Infants will be monitored by TcCO2 during three consecutive time periods of one hour each on a high and low rate of NIPPV, when in a stable condition. NIPPV rate will start high/low, changed to low/high and switched back to starting rate.

Description

This will be a prospective, crossover observational study that will be performed at Rambam NICU.

Infants will be monitored by TcCO2 during three consecutive time periods of one hour each on a high and low rate of NIPPV, when in a stable condition.

NIPPV rate will start high/low, changed to low/high and switched back to starting rate.

Details
Condition Bronchopulmonary Dysplasia
Treatment nasal intermittent positive pressure ventilation (NIPPV).
Clinical Study IdentifierNCT04836689
SponsorRambam Health Care Campus
Last Modified on18 April 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Gestational age 240 to 336
At least 6 hours of stabilized NIPPV settings, i.e. minor changes in settings (FiO2 0.10, PIP 2.0 cmH2O, RR 5 brm)
At least 6 hours of stabilized tcCO2, i.e. 5 mmHg variation
At least 6 hours from surfactant administration
Parental consent

Exclusion Criteria

If NIPPV set rate is 10 bpm and tcCO2 related pCO2 is<40mmHg
If NIPPV set rate is 30 bpm and tcCO2 related pCO2 is>60mmHg
Unstable infants due to acute conditions (sepsis. IVH), or congenital malformations
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