FOLFOXIRI Plus Cetuximab Versus FOLFOXIRI Plus Bevacizumab in Conversion Therapy of Right-sided Colon Cancer Liver Metastases

  • End date
    Dec 31, 2025
  • participants needed
  • sponsor
    Fudan University
Updated on 15 April 2021


To compare the efficacy of FOLFOXIRI plus Cetuximab and FOLFOXIRI plus Bevacuzumab in the conversion therapy of right-sided colon cancer liver metastases

Condition Liver Metastasis Colon Cancer
Treatment Cetuximab, bevacizumab, FOLFOXIRI
Clinical Study IdentifierNCT04832776
SponsorFudan University
Last Modified on15 April 2021


Yes No Not Sure

Inclusion Criteria

ECOG perfomance 0-1
pathologically confirmed colorectal carcinoma, with RAS wild type
inital unresectable liver metastases discussed by MDT
prior no systemical therapy or exceed 6 months after the adjuvant chemotherapy of primary tumor surgery
without extraheptic metastatic lesions, except for locally controlled lung metastases (RFA or SBRT)
adequate blood, liver and renal function
expected survival longer than 6 months

Exclusion Criteria

with bleeding risk
interestinal obstruction or disease
uncontrolled hypertension and severe heart disease
previous severe thrombotic events
central nervous system metastases
accompanied with other malignant tumor
Clear my responses

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