AIDA2000 - Risk-Adapted Therapy for Patients With Acute Promyelocytic Leukemia

  • STATUS
    Recruiting
  • participants needed
    80
  • sponsor
    Technische Universität Dresden
Updated on 22 January 2022
methotrexate
tretinoin
retinoids
maintenance therapy
induction therapy
consolidation therapy
mitoxantrone
idarubicin

Summary

In AIDA 2000 therapy of acute promyelocytic leukemia (APL) is given in a risk-adapted manner. Risk factors are age and white-blood-cell (WBC)-count at diagnosis. Induction therapy is done with ATRA and idarubicin followed by postremission therapy with daunorubicin and mitoxantrone in age adapted dosages. Patients with an high WBC were additionally treated with cytarabine. Finally a two year period of maintenance therapy with 6-mercaptopurine, methotrexate and ATRA is performed.

Description

In AIDA 2000 therapy of acute promyelocytic leukemia (APL) is given in a risk-adapted manner. Risk factors are age and white-blood-cell (WBC)-count at diagnosis. Induction therapy is done with ATRA and idarubicin followed by postremission therapy with daunorubicin and mitoxantrone in age adapted dosages. Patients with an high WBC were additionally treated with cytarabine. Finally a two year period of maintenance therapy with 6-mercaptopurine, methotrexate and ATRA is performed.

Details
Condition Leukemia, Promyelocytic, Acute
Treatment cytarabine, Mitoxantrone, Idarubicin, Daunorubicin, all-trans retinoid acid
Clinical Study IdentifierNCT00180128
SponsorTechnische Universität Dresden
Last Modified on22 January 2022

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