Bio-significance of LPC16:0 in Fibromyalgia

  • STATUS
    Recruiting
  • End date
    Jul 31, 2027
  • participants needed
    400
  • sponsor
    Kaohsiung Medical University Chung-Ho Memorial Hospital
Updated on 15 April 2021

Summary

Fibromyalgia (FM) is a very common but mysterious pain disorder characterized by chronic widespread muscular pain. Fatigue, anxiety and depression are common comorbidities. The syndrome is commonly associated with several symptoms, including fatigue, sleeping disturbance, cognitive impairment, and comorbid pain syndrome, especially irritable bowel symptoms and temporomandibular disease. Anxiety and depression are common psychiatric co-morbidies. Daily stress is believed to trigger or aggravate pain conditions. These symptoms can markedly affect patients' quality of life, and even lead to disability. So far, the etiology and pathogenesis are largely unknown, and diagnostic biomarkers and curative treatment remain to be developed. Recent technological advances enable scientists to explore mechanisms by genetic, transcriptomic, proteomic, and metabolomic researches. However, no definitive result has been concluded for clinical practice so far.

In this study, the investigators use tailored questionnaires to evaluate fibromyalgia and associated symptoms, including numeric rating scale for soreness, widespread soreness index, Fibromyalgia impact questionnaire, Hospital Anxiety and Depression Scale, and perceived stress scale. The investigators also use metabolomics and lipidomic approach to probe the potential pathophysiology of fibromyalgia. In our prior translation research (PMID: 32907805), the investigators found that excessive LPC16:0 resulting from lipid oxidization inflicts psychological stress-induced chronic non-inflammatory pain via activating ASIC3. In this content, our prior translational research identified a potential nociceptive ligand that causes fibromyalgia symptoms, which is likely to function as biomarkers for diagnosis or disease monitor. In the current clinical investigation, the investigators aim to reversely translate the novel findings in animal studies and validate the bio-significance of LPC16:0 for fibromyalgia with clinical approaches.

Details
Condition Fibromyalgia, Metabolomics, Physiological Stress, Pain, Acute Pain Service, Oxidative Stress, Stress, Post-Surgical Pain, Pain (Pediatric), ache, primary fibromyalgia syndrome, Soreness, Muscle, Lipidomics, Soreness, Muscle
Treatment Pregabalin 150mg, imipramine 25mg
Clinical Study IdentifierNCT04832100
SponsorKaohsiung Medical University Chung-Ho Memorial Hospital
Last Modified on15 April 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Clinical diagnosis of fibromyalgia

Exclusion Criteria

Systemic rheumatological or immune disorders (e.g., systemic lupus erythematosus, inflammatory myositis)
Systemic use of corticosteroids
Pregnancy
Chronic diseases under poor control
Malignancies
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