Extracorporeal Cytokine Adsorption as Additive Treatment of CAR-T Associated Cytokine Release Syndrome (CRS)

  • STATUS
    Recruiting
  • End date
    Sep 10, 2024
  • participants needed
    34
  • sponsor
    Hannover Medical School
Updated on 10 April 2021

Summary

Patients with severe CAR-T cell associated cytokine release syndrome (CRS) (defined as vasopressor dependent) will be treated with standard of care (SOC) + cytokine adsorption (6hourly for 24 hrs).

Primary endpoint is the change in plasma IL-6 between 0 and 24 hrs.

Details
Condition Cytokine Release Syndrome, CAR-T, CAR-T
Treatment CytoSorb
Clinical Study IdentifierNCT04048434
SponsorHannover Medical School
Last Modified on10 April 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

severe CRS (> 3) and / or severe CRES (>3)
AND
CRS/CRES onset < 6 hrs

Exclusion Criteria

Heparine allergy
contraindication for anticoagulation
Clear my responses

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