Temporal Relations and Exercise Interventions of Various Gait and Cognitive Domains in Older Adults

  • End date
    Dec 31, 2023
  • participants needed
  • sponsor
    Taipei Medical University
Updated on 11 October 2022
Accepts healthy volunteers


The effectiveness of conventional exercise, tai chi chuan and health education/usual physical activity over a 6-month intervention period in improving primary outcomes and secondary outcomes in older mild cognitive impairment adults will be compared. Third, whether changes in serum levels of the brain-derived neurotrophic factor (BDNF), insulin-like growth factor (IGF)-1, and vascular endothelial growth factor (VEGF) and expression of the apolipoprotein E (APOE) ε4 allele parallel changes in gait characteristics and cognitive functions after the intervention will be examined.

Condition Fallers, Mild Cognitive Impairment
Treatment Exercise
Clinical Study IdentifierNCT03839563
SponsorTaipei Medical University
Last Modified on11 October 2022


Yes No Not Sure

Inclusion Criteria

At least 65 years old
Had an emergency department visit due to a fall at least 3 months prior to the baseline assessment (assuming a full recovery time from a fall to be 3 months)
Can ambulate independently
Has mild cognitive impairment

Exclusion Criteria

Do not live in a community setting
Cannot ambulate independently and communicate with researchers
Have a major unstable cardiopulmonary disease (e.g., ischemic chest pain, shortness of breath, recurrent syncopal episodes, orthopnea, paroxysmal nocturnal dyspnea, palpitations, or tachycardia)
Have a contraindication to physical exercise (e.g., severe osteoarthritis or severe pulmonary hypertension)
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