A randomized, double-blinded, placebo-controlled, dose-escalation phase 1 clinical trial to evaluate the safety and immunogenicity of recombinant HIV-1 envelope protein BG505 SOSIP.GT1.1 gp140 Vaccine, Adjuvanted in healthy, HIV-uninfected adults

Updated on 6 April 2021


Researchers at The Rockefeller University are testing the safety of an investigational vaccine directed against HIV.


The purpose of this study is to find out if the study vaccine is safe and how the immune system responds to it. 

In addition, we hope to learn what kinds of side effects may be caused by the study vaccine, and how severe those side effects will be. This means that volunteers may experience the side effects listed in the risks section of the consent form for this protocol, or others that are not yet known.

Other HIV study products are being tested worldwide. At present, there is no licensed antibody-based product, injectable drug or vaccine to prevent HIV infection, but there are drug products taken by mouth that can be used to reduce the risk of HIV infection (pre-exposure prophylaxis, or PrEP).

Condition *Healthy Patient Studies, *Healthy Volunteers
Clinical Study IdentifierTX270577
Last Modified on6 April 2021


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Inclusion Criteria

Between the ages of 18 and 50
In good general health
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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