Translational characterization of blood pressure changes following the Dash Diet – from nutrition through electrolytes to exosomes

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Updated on 26 July 2021

Summary

Uncontrolled hypertension is a significant cause of illness and death from stroke, heart diseases and kidney failure. These can be reduced by adhering to the DASH diet, which reduces sodium and increases potassium intake. The mechanism of this "DASH effect" is not known and we suspect specific proteins in the kidney play an important role. We will try to understand the mechanism of the DASH effect by characterizing the change in proteins and salts excreted in the urine of otherwise healthy patients who switch from their usual western style diet to the DASH diet for two weeks, under close supervision.

Understanding the mechanism of the DASH effect could lead to new therapeutic approaches for treating hypertension. We will now include two cohorts, Caucasians and African Americans, as there is sufficient evidence for characterizing their responses to the DASH intervention. Research has shown that African Americans excrete less potassium, which may be related to salt sensitivity, in combination with potassium insensitivity. These physiological differences justify the two cohorts for which we propose to explore differences to the DASH intervention and may result in an augmented response to the intervention.

Description

Hypertension is one of the leading causes of morbidity and mortality in the industrialized world, attributed mostly to modifiable lifestyle factors. Aspects that are controlled by patients include physical activity, smoking, alcohol consumption, and nutrition. The DASH (Dietary Approach to Stop Hypertension) diet is a proven effective intervention in lowering blood pressure in multiple populations.

In this proof of concept study, volunteers with either untreated stage 1 hypertension, defined as mild high blood pressure with numbers in the range of 130 - 139 over 80 - 89, or stage 2 hypertension defined as 140-159mmhg systolic or 90-99mmHG diastolic, will receive a DASH-based menu during 5 days of hospitalization, during a weekend at home where they will continue the menu, another 5 days as inpatients, followed by a weekend at home on the same menu, and the return to the inpatient unit for an additional day for final testing.

Throughout the intervention period, participants will be followed clinically and undergo repeated laboratory testing. The aim of this project is to characterize changes in urine electrolytes and exosome protein abundance pattern during nutritional changes, shifting from a "westernized diet" to a DASH diet.

Details
Condition High Blood Pressure (Hypertension)
Clinical Study IdentifierTX270575
Last Modified on26 July 2021

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