The Role of Circadian Rhythms in Cancer-Related Symptoms

  • STATUS
    Recruiting
  • End date
    Jun 23, 2022
  • participants needed
    124
  • sponsor
    Aarhus University Hospital
Updated on 23 April 2021

Summary

Emerging evidence indicates that circadian rhythms may be disrupted following cancer and its treatment, and that circadian rhythm disruption may be an underlying pathophysiological mechanism of cancer- and cancer treatment-related symptoms (CRS) such as fatigue, sleep disturbance, cognitive impairment, and depressed mood. Given the detrimental effect of CRS on cancer survivors' quality of life, and a pressing demand for effective interventions to treat CRS, there is a need for a comprehensive examination of circadian disruption related to cancer and its treatment, and its association with CRS. The study will prospectively examine circadian rhythms and a CRS composite score in recently diagnosed breast cancer patients from prior to surgery or chemotherapy to 12 months later. A matched healthy control group will serve as a comparison.

Details
Condition Circadian Dysregulation, Endogenous depression, Depression, Depression (Adult and Geriatric), Depression (Treatment-Resistant), Depression (Major/Severe), Depression, Depression (Pediatric), Depression (Adolescent), Breast Cancer, Breast Cancer, Inflammation, Inflammation, Psychological stress, Quality of life, Sleep, Fatigue, Depression (Major/Severe), Depression (Adolescent), Depression (Pediatric), Depression (Adult and Geriatric), Depression (Treatment-Resistant), Cognitive Impairment, Cognitive Dysfunction, Breast Cancer Diagnosis, Depressed, Cognitive Impairments, tired, breast carcinoma, depressive disorder, fatigued, lack of energy, cancer, breast, neurocognitive disturbance, depressed mood, miserable, quality-of-life, depressive disorders, Cancer-Related Syndrome, Cancer-Related Syndrome, Cancer-Related Syndrome, Cancer-Related Syndrome
Clinical Study IdentifierNCT04401189
SponsorAarhus University Hospital
Last Modified on23 April 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients with early breast cancer scheduled for surgery and chemotherapy (neoadjuvant or adjuvant) at Aarhus University Hospital (AUH)
The healthy control group will consist of an age-matched sample of participants with no history of cancer

Exclusion Criteria

Pregnancy
Shift-work
Melatonin supplementation
Insufficient Danish proficiency
Previous cancer diagnosis except for treated non-melanoma skin cancer
Confounding diagnosed or suspected psychiatric or medical conditions that might significantly contribute to the CRS or symptoms/diagnoses resembling them (other than those caused by cancer or its treatment) such as seasonal affective disorder
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