The Effect of Monitoring PVP on Clinical Outcomes in Patients With PH

  • STATUS
    Recruiting
  • End date
    Dec 31, 2025
  • participants needed
    200
  • sponsor
    Nanfang Hospital of Southern Medical University
Updated on 4 April 2021

Summary

The complications associated with portal hypertension in cirrhosis are the main cause of death in patients with cirrhosis. The level of portal venous pressure is closely related to the prognosis of patients. HVPG (hepatic venous pressure gradient) is the "gold standard" for predicting portal venous pressure and an important indicator for evaluating the efficacy of NSBBS. However, monitoring HVPG has many limitationsand the clinical application is also limited to a certain extent. Therefore, this study intends to clarify the guiding value of monitoring portal venous pressure in the clinical diagnosis and treatment of portal hypertension patients through a single-center, prospective and observational study. Therefore, this study intends to clarify the guiding value of monitoring portal venous pressure in the clinical diagnosis and treatment of portal hypertension patients through a single-center, prospective and observational study. At the same time, to explore the correlation between HVPG and PPG in cirrhosis patients at different stages and different etiologies, and to evaluate the role of spleen stiffness in predicting the severity of esophageal and gastric varices in patients with portal hypertension, and to find biomarkers to predict the risk of complications related to portal hypertension.

Details
Condition LIVER DISEASE, LIVER DISEASE, Liver Disorders, Portal hypertension, Liver Disorders
Treatment monitoring portal pressure gradient or hepatic venous pressure gradient
Clinical Study IdentifierNCT04820166
SponsorNanfang Hospital of Southern Medical University
Last Modified on4 April 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

With chronic liver disease
Age 18-80 years
Patients who require a portal pressure measurement at the discretion of the treating physician
Voluntarily signed informed consent

Exclusion Criteria

With serious cardiopulmonary disease or other diseases affect survival
With severe renal dysfunction
Concomitant portal vein cavernous degeneration or extensive portal vein thrombosis
Women who are planning to become pregnant or who are pregnant or breastfeeding
The researcher judged that it was not suitable to participate in this study
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