Effect of Hormone Therapy on Renal Function

  • End date
    Jul 30, 2023
  • participants needed
  • sponsor
    University of Colorado, Denver
Updated on 7 April 2021


The purpose of this study is to understand the effects of testosterone or estradiol on kidney function in transgender adolescents and young adults.

Condition Nephropathy, Kidney Disease (Pediatric), Renal Injury, Kidney Injury, Kidney Disease, Transgenderism, renal disease, kidney diseases, kidney disorders, nephrologic disease, kidney disorder, disease, kidney
Treatment p-aminohippurate clearance study, Iohexol infusion
Clinical Study IdentifierNCT04482920
SponsorUniversity of Colorado, Denver
Last Modified on7 April 2021


Yes No Not Sure

Inclusion Criteria

Identify as transgender
Age 17-30 years (inclusive)
Plan to start gender affirming hormone therapy (testosterone or estradiol) clinically in 1 months and remain on for at least 3 months

Exclusion Criteria

Cognitive, psychiatric or physical impairment resulting in inability to tolerate the study procedures (e.g. intellectual disability, schizophrenia, hallucinations)
Type 1 or Type 2 diabetes
Chronic kidney disease, or eGFR <60ml/min/1.73m2 by CKD-EPI formulation
Uncontrolled hypertension (resting BP 140/90 mm/Hg)
Allergy to shellfish, iodine or iohexol
Currently taking: sulfonamides, procaine, thiazolesulfone and probenecid (renal clearance measurements of PAH cannot be made accurately if individuals are on these medications)
Prior gender affirming hormone therapy use
Prior gonadectomy
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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