DWI in the Diagnosis of Histological Types of Nephroblastoma in Children
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- STATUS
- Recruiting
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- End date
- Dec 21, 2023
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- participants needed
- 230
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- sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Summary
Initially, or after preoperative chemotherapy, patients with a kidney tumor are examined on 3T MR scanner or 1.5T MR scanner. A standard MRI study of the abdomen with contrast enhancement is performed. DWI (diffusion weighted) images are included in the standard investigation package and consist of diffusion maps. Then, using Philips workstation (ISP 9.0, Philips, Netherlands), DWI mapping and ADC values collection (mm2/s) are performed. The placement of region of interest (ROI) is selected in the kidney mass in a solid and cystic area with a size up to 100 mm2.
After the preoperative abdomen MRI, a surgical treatment is performed. Histological material is directed to the pathologist, who carried out the histological staging by the malignancy degree (low, intermediate, high). The data is entered into the database and the relationship between ADC values and histological degrees of malignancy of nephroblastoma is investigated
Description
Initially, or after preoperative chemotherapy, patients with a kidney tumor are examined on 3T MR scanner or 1.5T MR scanner, using 8-channel body coil. A standard MRI study of the abdomen with contrast enhancement is performed. DWI (diffusion weighted) images are included in the standard investigation package and consist of diffusion maps (DWI 3b) with 3 b-factors (50; 600; 800 or others, optional). Then, using Philips workstation (ISP 9.0, Philips, Netherlands), DWI mapping and ADC values collection (mm2/s) are performed. The placement of region of interest (ROI) is selected in the kidney mass in a solid and cystic area with a size up to 100 mm2. The values are entered in the table due to the stage of the chemotherapy.
After the preoperative abdomen MRI, a surgical treatment is performed. Histological material is directed to the pathologist, who carried out the histological staging by the malignancy degree (low, intermediate, high). The data is entered into the database and the relationship between ADC values and histological degrees of malignancy of nephroblastoma is investigated.
Details
| Condition | Malignant neoplasm of kidney, Kidney Cancer, Renal Cancer, Hereditary Neoplastic Syndrome, Hereditary Cancer Syndromes, Nephroblastoma, Wilms' Tumor, Kidney Cancer, Wilms' Tumor, Hereditary Cancer Syndromes, Renal Cancer |
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| Treatment | MRI DWI sequence (ADC values) |
| Clinical Study Identifier | NCT04814758 |
| Sponsor | Federal Research Institute of Pediatric Hematology, Oncology and Immunology |
| Last Modified on | 2 April 2021 |
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