DWI in the Diagnosis of Histological Types of Nephroblastoma in Children

  • STATUS
    Recruiting
  • End date
    Dec 21, 2023
  • participants needed
    230
  • sponsor
    Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Updated on 2 April 2021

Summary

Initially, or after preoperative chemotherapy, patients with a kidney tumor are examined on 3T MR scanner or 1.5T MR scanner. A standard MRI study of the abdomen with contrast enhancement is performed. DWI (diffusion weighted) images are included in the standard investigation package and consist of diffusion maps. Then, using Philips workstation (ISP 9.0, Philips, Netherlands), DWI mapping and ADC values collection (mm2/s) are performed. The placement of region of interest (ROI) is selected in the kidney mass in a solid and cystic area with a size up to 100 mm2.

After the preoperative abdomen MRI, a surgical treatment is performed. Histological material is directed to the pathologist, who carried out the histological staging by the malignancy degree (low, intermediate, high). The data is entered into the database and the relationship between ADC values and histological degrees of malignancy of nephroblastoma is investigated

Description

Initially, or after preoperative chemotherapy, patients with a kidney tumor are examined on 3T MR scanner or 1.5T MR scanner, using 8-channel body coil. A standard MRI study of the abdomen with contrast enhancement is performed. DWI (diffusion weighted) images are included in the standard investigation package and consist of diffusion maps (DWI 3b) with 3 b-factors (50; 600; 800 or others, optional). Then, using Philips workstation (ISP 9.0, Philips, Netherlands), DWI mapping and ADC values collection (mm2/s) are performed. The placement of region of interest (ROI) is selected in the kidney mass in a solid and cystic area with a size up to 100 mm2. The values are entered in the table due to the stage of the chemotherapy.

After the preoperative abdomen MRI, a surgical treatment is performed. Histological material is directed to the pathologist, who carried out the histological staging by the malignancy degree (low, intermediate, high). The data is entered into the database and the relationship between ADC values and histological degrees of malignancy of nephroblastoma is investigated.

Details
Condition Malignant neoplasm of kidney, Kidney Cancer, Renal Cancer, Hereditary Neoplastic Syndrome, Hereditary Cancer Syndromes, Nephroblastoma, Wilms' Tumor, Kidney Cancer, Wilms' Tumor, Hereditary Cancer Syndromes, Renal Cancer
Treatment MRI DWI sequence (ADC values)
Clinical Study IdentifierNCT04814758
SponsorFederal Research Institute of Pediatric Hematology, Oncology and Immunology
Last Modified on2 April 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age under 18 y.o
Renal mass with confirmed histology

Exclusion Criteria

Absolute contraindications to magnetic resonance imaging (pacemaker, ferromagnetic implants, etc.)
Refusal to sign the informed consent
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