Efficacy of Olanzapine Netupitant and Palonosetron in Controlling Nausea and Vomiting Associated With Highly Emetogenic Chemotherapy in Patients With Breast Cancer

  • STATUS
    Recruiting
  • participants needed
    50
  • sponsor
    Instituto Brasileiro de Controle do Cancer
Updated on 20 January 2022

Summary

This is a longitudinal, one arm, prospective phase II study, designed to evaluate the efficacy of Olanzapine Netupitant and Palonosetron in the controll of nausea and vomiting induced by highly emetogenic chemotherapy.

Description

The population of the study is women diagnosed with breast cancer, who will start chemotherapy (Doxorubicine and Cyclophosfamide). We will evaluate the control of nausea and vomiting in the first cycle of chemotherapy, utilizing Netupitant (300mg) + palonosetron (0,56mg) in day 1 and Olanzapine 5mg starting on Day 0, given once a day for five days. The primary endpoint of this study is complete response rate (no nausea, no emesis no use of rescue medication).

Details
Condition Nausea Post Chemotherapy
Treatment olanzapine, Netupitant, Palonesetron
Clinical Study IdentifierNCT04669132
SponsorInstituto Brasileiro de Controle do Cancer
Last Modified on20 January 2022

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