Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation

  • STATUS
    Recruiting
  • End date
    Mar 1, 2024
  • participants needed
    40
  • sponsor
    NYU Langone Health
Updated on 24 March 2022
Accepts healthy volunteers

Summary

This study is a prospective randomized trial examining the effect of topically combined antifibrinolytics (Tranexamic acid) with local anesthetics in all electively created surgical wound beds in hand surgery to provide long term pain relief and decrease the use of postoperative narcotics.

Description

The aim of the study is to provide long term pain relief and decrease the use of postoperative narcotics. All treatments are applied topically to the surgical bed prior to closure of the skin. Each of the drugs used in this study are Food and Drug Administration (FDA) approved and routinely used for pain relief. However, the route of administration of the drugs and addition of tranexamic acid or aminocaproic acid is considered off-label (outside of the FDA-approved indications) and therefore investigational.

Details
Condition Opioid Pain Medication
Treatment Tranexamic Acid, Aminocaproic acid, Aminocaproic acid, Recombinant Human Thrombin, Recombinant Human Thrombin, Lidocaine Hydrochloride with Epinephrine, Bupivacaine Hydrochloride with Epinephrine
Clinical Study IdentifierNCT04814433
SponsorNYU Langone Health
Last Modified on24 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 18 or older
Any patient undergoing elective hand surgery

Exclusion Criteria

Any patient with a traumatic open wound (only surgically created wounds will be included)
History of chronic pain
History of narcotic addiction
History of recreational drug dependency
History of psychiatric pathology
Allergy to local anesthetics, recombinant human thrombin or tranexamic acid
Any patient receiving a supra/infraclavicular block for anesthesia
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