Optimal Dosing of IC-Green for Visualization of Rotator Cuff Vascularity Using Advanced Imaging Modality Arthroscopy: A Prospective, Randomized Trial

  • End date
    Sep 1, 2023
  • participants needed
  • sponsor
    NYU Langone Health
Updated on 28 October 2022


Rotator cuff re-tear is a common delayed complication of arthroscopic rotator cuff repair. This process of re-tear is multifactorial and there has not been any readily identifiable perioperative measure that is predictive of subsequent rotator cuff failure. There have been no human studies looking at intraoperative assessment of rotator cuff vascularity, nor the predictive value that vascularity may have for rotator cuff re-tear. Indocyanine Green (ICG) has been safely used in patients for visualization purposes and has real potential for identifying vascularity in arthroscopic surgical patients. The aim of this study is to establish a standard dosing protocol for ICG in the arthroscopic visualization of rotator cuff vascularity.


The primary study objective is to determine optimal dosing of an intravenous fluorescence solution (IC-Green) for arthroscopic evaluation of rotator cuff vascularity. The primary endpoint is surgeon's ability to assess vascularity within the rotator cuff based on a 5-point likert scale. The likert values from each of the three doses will undergo an ANOVA test to compare means of the three doses.

Condition Rotator Cuff Tears
Treatment Indocyanine Green
Clinical Study IdentifierNCT04340752
SponsorNYU Langone Health
Last Modified on28 October 2022


Yes No Not Sure

Inclusion Criteria

Patients has full or partial thickness rotator cuff tear and is scheduled to undergo arthroscopic rotator cuff repair
Patient is at least 18 years of age and less than 80 years of age

Exclusion Criteria

Patient is less than 18 years of age or greater than 79 years of age
Patient has a documented allergy to iodides
Patients who have had iodide based radiology studies within the last seven (7) days prior to surgery
Patient is pregnant
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