Atorvastatin as Adjunctive Therapy in COVID-19

  • participants needed
  • sponsor
    Mount Auburn Hospital
Updated on 8 August 2022


Objective: To assess whether adjunctive therapy of COVID-19 infection with atorvastatin reduces the deterioration in hospitalized patients and improves clinical outcome.


COVID-19 is caused by SARS-CoV-2, a -coronavirus that binds to the zinc peptidase angiotensin-converting enzyme 2 (ACE2). No drug is licensed to treat COVID-19, but adjunctive pharmacologic interventions have been proposed for their immunomodulatory effects, including statins. About 5% of cases are considered critical, with severe respiratory failure as well as myocarditis, and thromboses, and are associated with high fatality rate. Statins affect endothelial dysfunction and have anti-inflammatory and immunomodulatory effects.

This prospective, randomized, open-label trial of atorvastatin as adjunctive treatment of COVID-19 in hospitalized patients aims to study:

  1. Will atorvastatin reduce progression to severe or critical COVID-19 disease and death compared to standard care?
  2. Will atorvastatin lead to improved clinical outcome of COVID-19 disease at 30 days compared to standard care?

Condition *COVID-19, Covid-19
Treatment Atorvastatin
Clinical Study IdentifierNCT04380402
SponsorMount Auburn Hospital
Last Modified on8 August 2022

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