Cognitive Fitness for Depression in Older Adults

  • End date
    Aug 31, 2024
  • participants needed
  • sponsor
    UConn Health
Updated on 22 January 2022


This research is being done to determine if computerized administered cognitive fitness activities will improve thinking and depression in older depressed adults who are being treated with antidepressants. The investigators are also interested in whether participating in the treatment will result in changes to brain activity measured with magnetic resonance imaging (MRI).


Major depression in the elderly is both challenging to treat and detrimental to the cognitive functioning of patients. Major depression increases the probability of a later dementia diagnosis. By targeting cognitive processes in treatment, the investigators hope to both find a more effective means to manage major depression in older adults, but also demonstrate how top-down processes (e.g., Executive Control Network) may be driving depression and cognitive decline in older adults.

The investigators are recruiting older adults with and without mild cognitive impairment. All subjects must have at least mild depressive symptoms to be eligible to participate. Subjects will be randomly assigned to one of two different interventions.

Results of this study will help the investigators understand the mechanisms that contribute to depressed mood and cognitive change in older adults with late life depression.

Condition Depression Mild, Depressive Disorder, Major, Mild Cognitive Impairment
Treatment Active control, Computerized Cognitive Remediation of Executive Functioning (CCR-EF)
Clinical Study IdentifierNCT04790630
SponsorUConn Health
Last Modified on22 January 2022


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Inclusion Criteria

ability to read and write in English
current major or mild depression despite ongoing treatment
under the care of a physician who prescribes medication for depression
currently treated with an antidepressant for at least 8 weeks

Exclusion Criteria

other psychiatric disorders (except personality & generalized anxiety disorders)
substance use disorders in the prior year
clinical diagnosis of dementia
neurological disorders (e.g., stroke, epilepsy, brain injury with loss of consciousness > 30 minutes, brain tumors, demyelinating diseases)
corrected visual acuity < 20/70 or color blindness
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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